Title of article
Rapid and convenient synthesis of aryl- and heteroaryl-α-hydroxy-α-trifluoromethyl acetate via Friedel–Crafts alkylation under solvent- and catalyst-free conditions
Author/Authors
Zhao، نويسنده , , Junling and Liu، نويسنده , , Li and Zhang، نويسنده , , Haibo and Wu، نويسنده , , Yanchao and Wang، نويسنده , , Dong and Chen، نويسنده , , Yong Jun، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
2511
To page
2514
Abstract
Solvent- and catalyst-free Friedel–Crafts alkylation reactions of aromatic and heteroaromatic compounds with methyl trifluoropyruvate (2) were carried out at room temperature and finished in several minutes with good to excellent yields of the addition products (69→99%), which provided a rapid and convenient method to synthesize aryl- and heteroaryl-α-hydroxy-α-triflouromethyl acetates.
Keywords
Solvent- and catalyst-free , Friedel–Crafts alkylation , ?-Hydroxy-?-trifluoromethyl carboxylate
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1849499
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