Author/Authors :
Ilyin، نويسنده , , Alexey P. and Parchinski، نويسنده , , Vladislav Z. and Peregudova، نويسنده , , Julia N. and Trifilenkov، نويسنده , , Andrey S. and Poutsykina، نويسنده , , Elena B. and Tkachenko، نويسنده , , Sergey E. and Kravchenko، نويسنده , , Dmitri V. and Ivachtchenko، نويسنده , , Alexandre V.، نويسنده ,
Abstract :
We present a convenient synthesis of heterocyclic scaffolds using a novel modification of four-component Ugi condensation. Two complementary variants of this useful synthetic strategy provide an efficient one-step assembly of four novel pharmaceutically relevant (hetero)aryl-fused 1,4-oxazepines with different substituents’ profile.
Keywords :
4-oxazepine-3-carboxamide , 5-Oxo-1 , 3-Oxo-1 , 4-oxazepine-5-carboxamide , Parallel synthesis , Compound library , Ugi condensation
