Title of article :
High throughput evaluation of the production of substituted acetylenes by the Sonogashira reaction followed by the Mizoroki–Heck reaction in ionic liquids, in situ, using a novel array reactor
Author/Authors :
Rahman، نويسنده , , Md. Taifur and Fukuyama، نويسنده , , Takahide and Ryu، نويسنده , , Ilhyong and Suzuki، نويسنده , , Kanae and Yonemura، نويسنده , , Koichi and Hughes، نويسنده , , Philip F. and Nokihara، نويسنده , , Kiyoshi، نويسنده ,
Abstract :
The parallel Sonogashira coupling reaction was carried out under copper-free condition by integrating the advantages of ionic liquids as the reaction media followed by the simultaneous-multiple Mizoroki–Heck reaction in situ by the use of a novel array reactor (SynArray-24). The device provides rapid evaluation of reactions in a short period.
Keywords :
Array reactor , Sonogashira reaction , Mizoroki–Heck reaction , Combinatorial solution synthesis
