Author/Authors :
Sohma، نويسنده , , Youhei and Taniguchi، نويسنده , , Atsuhiko and Skwarczynski، نويسنده , , Mariusz and Yoshiya، نويسنده , , Taku and Fukao، نويسنده , , Fukue and Kimura، نويسنده , , Tooru and Hayashi، نويسنده , , Yoshio and Kiso، نويسنده , , Yoshiaki، نويسنده ,
Abstract :
A novel ‘O-acyl isodipeptide unit’, Boc-Thr(Fmoc-Val)-OH 5 has been successfully used for the efficient synthesis of a difficult sequence-containing pentapeptide based on the ‘O-acyl isopeptide method’, in which racemization-inducible esterification could be omitted, suggesting that the use of O-acyl isodipeptide units allows the application of this method to fully automated protocols for the synthesis of long peptides or proteins.
Keywords :
O-Acyl isodipeptide unit , O-Acyl isopeptide method , O–N Intramolecular acyl migration , Difficult sequence
