A highly regioselective synthesis of 2-aryl-6-chlorobenzothiazoles employing microwave-promoted Suzuki–Miyaura coupling reaction

Suzuki–Miyaura coupling reactions of 2,6-dichlorobenzothiazole with arylboronic acids, promoted by microwave heating, efficiently produce 2-aryl-6-chlorobenzothiazoles in a highly regioselective manner. This process serves as the foundation for a simple method to rapidly construct 2-aryl-6-chlorobenzothiazole libraries.