Trichiol and 3-epitrichiol acetate, novel cytotoxic sterols with an unprecedented 2,6-dioxabicyclo[2.2.2]octan-3-one ring system from the myxomycete Trichia favoginea var. persimilis

Trichiol (1) and 3-epitrichiol acetate (2), two new sterols, have been isolated from field-collected fruit bodies of the myxomycete, Trichia favoginea var. persimilis, and their structures elucidated by spectral data. Trichiol (1) and 3-epitrichiol acetate (2) possess an unprecedented 2,6-dioxabicyclo[2.2.2]octan-3-one ring system. Trichiol (1) was cytotoxic against HeLa cells, while compound 2 proved to exhibit reversal effect against TNF-related apoptosis inducing ligand (TRAIL)-resistant Jurkat cell lines.