Title of article
Studies toward the synthesis of salinosporamide A, a potent proteasome inhibitor
Author/Authors
Virginie Caubert، نويسنده , , Virginie and Langlois، نويسنده , , Nicole، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
3
From page
4473
To page
4475
Abstract
An α-methylenepyrrolidinone bearing all the functionalities and relative configurations of an advanced intermediate in the synthesis of salinosporamide A and analogues has been synthesized from methyl pyroglutamate through regio- and stereoselective N-methylnitrone cycloaddition.
Keywords
protease inhibitor , Salinosporamide A , pyroglutamate , 1 , 3-dipolar cycloadditions , Diazomethane , N-Methylnitrone , Samarium diiodide
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850857
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