Author/Authors :
Di Paola، نويسنده , , Rosanna and Di Marco، نويسنده , , Roberto and Mazzon، نويسنده , , Emanuela and Genovese، نويسنده , , Tiziana and Bendtzen، نويسنده , , Klaus and Macr??، نويسنده , , Battesimo and Nicoletti، نويسنده , , Ferdinando and Cuzzocrea، نويسنده , , Salvatore، نويسنده ,
Abstract :
CD30 ligand (CD30L) and its receptor CD30 are members of the tumor necrosis factor (TNF) and TNF receptor superfamilies that play a major role in inflammation and immune regulation. To gain insight into the in vivo role of CD30L/CD30 in inflammatory diseases, we have used carrageenan (CAR)-induced pleurisy in mice, a preclinical model of airway inflammation where type 1 proinflammatory cytokines such as interleukin (IL)-1 and TNF-α play a key pathogenic role.
ta show that prophylactic treatment with anti-CD30L mAb markedly reduces both laboratory and histological signs of CAR-induced pleurisy. These data suggest involvement of CD30-mediated signals in acute immunoinflammatory pathways induced by CAR.
