Title of article
First synthesis of (+)-8-methoxygoniodiol and its analogue, 8-deoxygoniodiol, using a three component strategy
Author/Authors
Carreaux، نويسنده , , François and Favre، نويسنده , , Annaick and Carboni، نويسنده , , Bertrand and Rouaud، نويسنده , , Isabelle and Boustie، نويسنده , , Joel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
4545
To page
4548
Abstract
We have described the first total synthesis of the natural product, (+)-8-methoxygoniodiol, and its analogue, 8-deoxygoniodiol using a catalytic asymmetric hetero-Diels–Alder/allylboration sequence involving three partners. The cytotoxic activity of these final compounds and of two synthetic intermediates has been evaluated against human cancer cell lines (A375P and A375M), showing the importance of the lactone moiety.
Keywords
Asymmetric catalysis , hetero-Diels–Alder , natural product , cytotoxicity , Allylboration reaction , 8-Deoxygoniodiol , (+)-8-Methoxygoniodiol
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1850891
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