Title of article
Differential expression of interferon-γ and interferon-γ-inducing cytokines in Thai patients with scrub typhus or leptospirosis
Author/Authors
Wirongrong Chierakul، نويسنده , , Wirongrong and de Fost، نويسنده , , Maaike and Suputtamongkol، نويسنده , , Yupin and Limpaiboon، نويسنده , , Roongreung and Dondorp، نويسنده , , Arjen and White، نويسنده , , Nicholas J. and van der Poll، نويسنده , , Tom، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2004
Pages
5
From page
140
To page
144
Abstract
Interferon (IFN)-γ plays an important role in the induction of a type 1 immune response against intracellular pathogens. We compared the plasma levels of IFN-γ and IFN-γ-inducing cytokines in adult Thai patients with scrub typhus, caused by the obligate intracellular bacterium Orientia tsutsugamushi, and leptospirosis, caused by extracellular Leptospira interrogans. IFN-γ, interleukin (IL)-18, and IL-15 levels were elevated only in patients with scrub typhus, whereas IL-12p40 and tumor necrosis factor-α concentrations were elevated in both patient groups, although more so in scrub typhus. These data suggest a role for a cell-mediated immune response in host defense against O. tsutsugamushi.
Keywords
IL-12 , Scrub typhus , IFN-? , Leptospirosis
Journal title
Clinical Immunology
Serial Year
2004
Journal title
Clinical Immunology
Record number
1850898
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