Author/Authors :
Kalinski، نويسنده , , Cédric and Umkehrer، نويسنده , , Michael and Schmidt، نويسنده , , Jürgen and Ross، نويسنده , , Günther and Kolb، نويسنده , , Jürgen and Burdack، نويسنده , , Christoph and Hiller، نويسنده , , Wolfgang H. Hoffmann، نويسنده , , Stephan D.، نويسنده ,
Abstract :
A novel one-pot two-step multi component reaction of acrylic aldehydes, bromoanilines, acids and isocyanides yielding polysubstituted indoles is described. The reaction is based on the combination of an Ugi four-component reaction followed by an intramolecular Heck-reaction. The simultaneous use of formic acid and cinnamaldehydes affords in situ generation of 1H-indoles. Convertible isocyanides can also be used with success in this Ugi/Heck strategy and enable synthesis of 1H-indole-2-carboxylic acid building blocks.
Keywords :
Ugi–reaction , Ugi–Heck reaction , Isocyanide-based multi-component reactions (IMCRs) , Combinatorial chemistry , indole
