Title of article :
Differential Expression of Fas Antigen and Bcl-2 Protein on CD4+ T Cells, CD8+ T Cells, and Monocytes
Author/Authors :
Shinohara، نويسنده , , Satoshi and Sawada، نويسنده , , Tetsuji and Nishioka، نويسنده , , Yuichi and Tohma، نويسنده , , Shigeto and Kisaki، نويسنده , , Tomonari and Inoue، نويسنده , , Tetsufumi and Ando، نويسنده , , Kayo and Ikeda، نويسنده , , Makoto and Fujii، نويسنده , , Hitoshi and Ito، نويسنده , , Koji، نويسنده ,
Abstract :
Fas antigen and Bcl-2 protein are considered to be involved in cellular homeostasis. We precisely analyzed the expression of human Fas antigen and Bcl-2 protein on CD4+ T cells, CD8+ T cells, and monocytes. The positivities of Fas antigen on CD4+ and CD8+ T cells increased with aging. In CD4+ T cells, the Fas-/CD45RO+ subpopulation was dominant compared with the Fas+/CD45RO- subpopulation. Conversely, in CD8+ T cells, the Fas+/CD45RO- subpopulation was dominant compared with the Fas-/CD45RO+ subpopulation. Monocytes exhibited high positivity of Fas antigen and low fluorescence intensity of Bcl-2 protein compared with T cells. These results suggest that Fas antigen acts in different processes of cellular homeostasis between CD4+ and CD8+ T cells and that expression of Fas antigen and Bcl-2 protein is involved in homeostasis of monocytes as well as lymphocytes.
