Title of article
A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides
Author/Authors
Rajapakse، نويسنده , , Hemaka A. and Zhu، نويسنده , , Shi-Hong and Young، نويسنده , , Mary Beth and Mott، نويسنده , , Bryan T.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
4827
To page
4830
Abstract
A convenient one pot method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acids and acyl hydrazides is reported. Acid activation with CDI, followed by coupling with the desired acylhydrazide and dehydration in the same pot with Ph3P and CBr4 affords the corresponding 1,3,4-oxadiazoles in good yield. The scope of the acid and acylhydrazide components is presented.
Keywords
1 , 3 , 4-oxadiazole , One pot , Synthesis
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1851209
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