Title of article
One-step deprotonation route to zinc amide and ester enolates for use in aldol reactions and Negishi couplings
Author/Authors
Hlavinka، نويسنده , , Mark L. and Hagadorn، نويسنده , , John R.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
5
From page
5049
To page
5053
Abstract
Simple amides and esters are conveniently deprotonated by Zn(tmp)2 (tmp = 2,2,6,6-tetramethylpiperidinyl anion) to generate Zn enolates. Enolates formed by this method are suitable for use in aldol reactions that tolerate base-sensitive functional groups. Additionally, the Zn enolates are readily coupled with aryl bromides using typical Pd-catalyzed coupling methods.
Keywords
aldol , Negishi coupling , Zinc , Ester enolate , reformatsky , Amido , Amide enolate
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1851305
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