Author/Authors :
Natarajan، نويسنده , , Swaminathan R. and Chen، نويسنده , , Meng-Hsin and Heller، نويسنده , , Stephen T. and Tynebor، نويسنده , , Robert M. and Crawford، نويسنده , , Ellen M. and Minxiang، نويسنده , , Cui and Kaizheng، نويسنده , , Han-Bang Dong، نويسنده , , Jingchao and Hu، نويسنده , , Bin and Hao، نويسنده , , Wu and Chen، نويسنده , , Shu-Hui، نويسنده ,
Abstract :
A rapid entry into the 2H-quinolizin-2-one starting from 2-alkyl pyridine has been developed. Initial deprotonation of a 2-alkyl pyridine followed by acylation with a β-TMS-propyonate derivative provides acyclic precursors that after deprotection undergoes a 6-endo-trig cyclization to yield the desired 2H-quinolizin-2-one derivative. This synthetic strategy was found to be generally applicable as evidenced from the various examples in this letter.
