Title of article :
Synthesis of 2′,3′-dideoxynucleosides via C–S bond cleavage: N-glycosylation of 2,3-dideoxy-1-[(2-pyridylmethyl)thio]glycoside
Author/Authors :
Mitsudo، نويسنده , , Koichi and Matsuda، نويسنده , , Wataru and Miyahara، نويسنده , , Seiji and Tanaka، نويسنده , , Hideo، نويسنده ,
Abstract :
N-Glycosylation of 2,3-dideoxy-1-[(2-pyridylmethyl)thio]glycosides (1a) using several activators is described. NBS-promoted glycosylation reaction utilizing either the α- or β-thiodideoxyglycoside proceeded smoothly at −78 °C to give the corresponding dideoxynucleoside in a β-selective manner, presumably through a common glycosyl donor.
