Title of article
Enzymatic kinetic resolution of 1,1-dioxo-2,3-dihydro-1H-1λ6-thiophen-3-ol via temporary derivatisation
Author/Authors
Morgan، نويسنده , , Ben S. and Roberts، نويسنده , , Stanley M. and Evans، نويسنده , , Paul، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
5273
To page
5276
Abstract
Following the thio-conjugate addition of (±)-9, its enantiomers were extremely efficiently discriminated using Novozym 435®. The thio-differentiating unit may then be removed either under reductive conditions, using Raney nickel, or following an oxidation–elimination sequence. In this manner enantioenriched derivatives of 1,1-dioxo-2,3-dihydro-1H-1λ6-thiophen-3-ol 9 may be accessed.
Keywords
Enzymatic kinetic resolution , Cyclic sulfone , Temporary derivatisation
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1851431
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