Author/Authors :
Ohkura، نويسنده , , Kazue and Nishijima، نويسنده , , Ken-ichi and Sanoki، نويسنده , , Kimihito and Kuge، نويسنده , , Yuji and Tamaki، نويسنده , , Nagara and Seki، نويسنده , , Koh-ichi، نويسنده ,
Abstract :
β-(N-Benzoylamino)methacrylamide, a key intermediate for the preparation of [2-11C]thymine, was synthesized in three steps from ethyl α-formylpropionate and NH3. Reaction of the alkali metal salts of β-(N-benzoylamino)methacrylamide with [11C]phosgene gave [2-11C]thymine. The yield of [2-11C]thymine was 362 ± 53 MBq at EOS (n = 3) (18 MeV proton beam; 10 μA, 10 min). The total synthesis was accomplished in just 16 min from the end of bombardment.
