Title of article
Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction
Author/Authors
Takahashi، نويسنده , , Hideo K. and Xue، نويسنده , , Dong and Iwagaki، نويسنده , , Hiromi and Tamura، نويسنده , , Ryuji and Katsuno، نويسنده , , Goutarou and Yagi، نويسنده , , Takahito and Yoshino، نويسنده , , Tadashi and Mori، نويسنده , , Shuji and Nishibori، نويسنده , , Masahiro and Tanaka، نويسنده , , Noriaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
8
From page
85
To page
92
Abstract
Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-γ and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect.
Keywords
IL-18 , MLR , human , Prostaglandin , Adhesion molecule
Journal title
Clinical Immunology
Serial Year
2005
Journal title
Clinical Immunology
Record number
1851474
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