Author/Authors :
Takahashi، نويسنده , , Hideo K. and Xue، نويسنده , , Dong and Iwagaki، نويسنده , , Hiromi and Tamura، نويسنده , , Ryuji and Katsuno، نويسنده , , Goutarou and Yagi، نويسنده , , Takahito and Yoshino، نويسنده , , Tadashi and Mori، نويسنده , , Shuji and Nishibori، نويسنده , , Masahiro and Tanaka، نويسنده , , Noriaki، نويسنده ,
Abstract :
Prostaglandin E1 (PGE1) has therapeutic value for transplantations due to its microvascular activity. Interleukin (IL)-18, which is elevated in plasma during the acute rejection after organ transplantation, elicits the expression of intercellular adhesion molecule (ICAM)-1, B7.1, B7.2, CD40, and CD40 ligand (CD40L) on monocytes as well as the production of interferon (IFN)-γ and IL-12 and proliferation of T-cells during the human mixed lymphocyte reaction (MLR) in an in vitro model of acute rejection. In contrast, PGE1 inhibits all the adhesion molecule expression, cytokine production and T-cell proliferation in the presence of IL-18. The effects of PGE1 depend on stimulation of the IP/EP2/EP4-receptor, and thus, PGE1 might have therapeutic potential for treating acute rejection due to its immune regulatory effect.
Keywords :
IL-18 , MLR , human , Prostaglandin , Adhesion molecule
