Author/Authors :
Kawasaki، نويسنده , , Tomomi and Takamiya، نويسنده , , Wataru and Okamoto، نويسنده , , Naoki and Nagaoka، نويسنده , , Miyuki and Hirayama، نويسنده , , Tetsuya، نويسنده ,
Abstract :
Asymmetric Claisen rearrangement triggered by silyl-enolization of 2-(1′-nonel-3′-yloxy)indolin-3-ones was performed in order to prepare 3-(2′-nonenyl)-3-hydroxyindolin-2-ones. Total synthesis of 3-hydroxypyrrolo[2,3-b]indoline alkaloid, (+)-alline was achieved by transformation of the allylic moiety of 3-(2′-nonenyl)-3-hydroxyindolin-2-one to amine followed by reductive cyclization.
