Title of article
E-Ring extended estrone derivatives: introduction of 2-phenylcyclopentenone to the estrone D-ring via an intermolecular Pauson–Khand reaction
Author/Authors
Kaasalainen، نويسنده , , Emmi and Tois، نويسنده , , Jan and Russo، نويسنده , , Luca and Rissanen، نويسنده , , Kari and Helaja، نويسنده , , Juho، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
5669
To page
5672
Abstract
An expedient synthetic route to E-ring extended estrone derivatives is reported. Estrone-derived cyclopentenones were accessed by an intermolecular Pauson–Khand (PK) cycloaddition. It was found that electron donating and withdrawing substituents in the arylalkyne increased and decreased the yields of PK products, respectively. The stereochemistry of the products was elucidated by X-ray and NMR studies.
Keywords
Estrone , Intermolecular Pauson–Khand reaction , Steroids
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1851607
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