Author/Authors :
Novak، نويسنده , , Andrew and Humphreys، نويسنده , , Luke D. and Walker، نويسنده , , Matthew D. and Woodward، نويسنده , , Simon، نويسنده ,
Abstract :
Synthesis of amides from coupling esters with a range of primary amines can be conveniently achieved in moderate to excellent yields (69–99%) using an air-stable adduct of trimethylaluminium (AlMe3)2·DABCO (DABCO is 1,4-diazobicyclo[2.2.2]octane), referred to as DABAL–Me3. Reactions can be run without requiring the exclusion of atmospheric oxygen or the drying of solvents.
