Title of article :
Modification of guanine residues in PNA-synthesis by PyBOP
Author/Authors :
Pritz، نويسنده , , Stephan E. Wolf، نويسنده , , Yvonne and Klemm، نويسنده , , Clementine and Bienert، نويسنده , , Michael، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
The phosphonium-type coupling reagent PyBOP, when applied to the synthesis of peptide nucleic acid (PNA) oligomers, was found to form O4-phosphonium compounds of the nucleobase guanine which can be converted into C4-modified guanine-derived PNAs by nucleophiles.
Keywords :
Coupling reagents , PNA synthesis , PyBOP , guanine , HATU
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
