Title of article
Facile synthesis of Nε-(benzyl, methyl)-lysine as a building block for site-specifically lysine monomethylated peptides
Author/Authors
Huang، نويسنده , , Zhiping and Su، نويسنده , , Xiao-Yang and Du، نويسنده , , Jin-Tang and Zhao، نويسنده , , Yufen and Li، نويسنده , , Yan-Mei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
3
From page
5997
To page
5999
Abstract
Facile, mild and efficient one-pot preparation of Nα-Fmoc-Nε-(benzyl, methyl)-lysine, a building block for monomethylated peptide synthesis, was described. This building block was proved to be efficient for the synthesis of site-specifically monomethylated peptide. Benzyl group, which was incorporated by reductive benzylation and removed via catalytic hydrogenolysis, served as an excellent protecting group.
Keywords
Lysine , Methylation , benzylation , Monomethylated peptide
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852025
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