Title of article
A convergent synthesis of the macrolide core of migrastatin
Author/Authors
Sai Baba، نويسنده , , V. and Das، نويسنده , , Parthasarathi and Mukkanti، نويسنده , , K. and Iqbal، نويسنده , , Javed، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
6083
To page
6086
Abstract
We describe an efficient synthesis of the 14-membered macrolide core 2 of migrastatin via key intermediate 3 employing a diastereoselective aldol condensation, Lewis acid mediated diastereoselective addition and an exclusive (Z)-olefination sequence. Yamaguchi esterification of the key intermediate 3 followed by ring-closing metathesis (RCM) produced macrolide 2 with high selectivity and good yield.
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852062
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