Title of article
Efficient synthesis of tetramethylsulfonylguanidines between a free sulfonamide group and HBTU
Author/Authors
Gluszok، نويسنده , , Sébastien and Goossens، نويسنده , , Laurence and Depreux، نويسنده , , Patrick and Hénichart، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
6087
To page
6090
Abstract
The reaction of a sulfonamide moiety with HBTU (O-(1H-benzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphate) during amide coupling, leading to the formation of tetramethylsulfonylguanidines, is described. Optimised conditions showed that HBTU was as a convenient agent for the synthesis of tetramethylsulfonylguanidines, in basic conditions. A panel of diverse sulfonamides was used to demonstrate the scope of this procedure.
Keywords
HBTU , Tetramethylsulfonylguanidines , Sulfonamide
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852066
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