Author/Authors :
Rank، نويسنده , , Christian and Phipps، نويسنده , , Richard Kerry and Harris، نويسنده , , Pernille and Frisvad، نويسنده , , Jens Christian and Gotfredsen، نويسنده , , Charlotte Held and Larsen، نويسنده , , Thomas Ostenfeld Larsen، نويسنده ,
Abstract :
Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data. The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A.
