Title of article
Synthesis of 28-19F-amphotericin B methyl ester
Author/Authors
Tsuchikawa، نويسنده , , Hiroshi and Matsushita، نويسنده , , Naohiro and Matsumori، نويسنده , , Nobuaki and Murata، نويسنده , , Michio and Oishi، نويسنده , , Tohru، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
5
From page
6187
To page
6191
Abstract
A fluorinated amphotericin B (AmB) derivative, 28-19F-AmB methyl ester (3), labeled at the polyene moiety, was synthesized by combining chemical synthesis with degradation of a natural product via cross-coupling reactions and macrolactonization. The fluorinated derivative 3 showed antifungal activity similar to that of AmB, and is expected to be a powerful tool for NMR-based investigation of the mechanism of ion-channel formation.
Keywords
Amphotericin B , fluorine , natural product , Degradation , NMR , chemical synthesis
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852124
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