Title of article
A rate enhancement of tert-butoxycarbonylation of aromatic amines with Boc2O in alcoholic solvents
Author/Authors
Vilaivan، نويسنده , , Tirayut، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
4
From page
6739
To page
6742
Abstract
A rate enhancement of tert-butoxycarbonylation of aromatic amines by Boc2O in alcohols compared to aprotic solvents was demonstrated. Kinetic analysis by NMR suggested that the reaction in CD3OD was faster than in CDCl3 by a factor of 70. Reactions between Boc2O and various aliphatic and aromatic amines in ethanol provided the N-Boc derivatives in good to excellent yields in short reaction times.
Keywords
Protecting group , Boc2O , Amine
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852443
Link To Document