Author/Authors :
Bosse، نويسنده , , Kristopher and Marineau، نويسنده , , Jason and Nason، نويسنده , , Deane M. and Fliri، نويسنده , , Anton J. and Segelstein، نويسنده , , Barb E. and Desai، نويسنده , , Kishor and Volkmann، نويسنده , , Robert A.، نويسنده ,
Abstract :
Use of alkyl substituted propylene linkers as a strategy for fine-tuning the biological activity of medicinal agents requires ready access to these substrates. Herein, a general strategy is described for stereospecifically generating 18 chiral mono- and di-methylpropylene linkers. All twelve vicinal 1,2-propylene targets were generated from methyl-3-hydroxybutanoate and all 1,3-disubstituted targets from pentane-2,4-diol.
