Title of article
Expanding the medicinal chemistry toolbox: stereospecific generation of methyl group-containing propylene linkers
Author/Authors
Bosse، نويسنده , , Kristopher and Marineau، نويسنده , , Jason and Nason، نويسنده , , Deane M. and Fliri، نويسنده , , Anton J. and Segelstein، نويسنده , , Barb E. and Desai، نويسنده , , Kishor and Volkmann، نويسنده , , Robert A.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
3
From page
7285
To page
7287
Abstract
Use of alkyl substituted propylene linkers as a strategy for fine-tuning the biological activity of medicinal agents requires ready access to these substrates. Herein, a general strategy is described for stereospecifically generating 18 chiral mono- and di-methylpropylene linkers. All twelve vicinal 1,2-propylene targets were generated from methyl-3-hydroxybutanoate and all 1,3-disubstituted targets from pentane-2,4-diol.
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852731
Link To Document