Title of article
Phosphomimetic sulfonamide and sulfonamidoxy analogues of (Lyso)phosphatidic acid
Author/Authors
Joanna Gajewiak، نويسنده , , Joanna and Prestwich، نويسنده , , Glenn D.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2006
Pages
3
From page
7607
To page
7609
Abstract
Lysophosphatidic acid (LPA) and phosphatidic acid (PA) are potent bioactive lipid mediators of signal transduction and are inactivated by phosphatases. To obtain receptor-isoform selective ligands with neutral phosphomimetic head groups, we performed the stereoselective synthesis of LPA and PA analogues with trifluoromethanesulfonamide and trifluoromethanesulfonamidoxy moieties replacing the phosphomonoester.
Keywords
Stereoselective phospholipid synthesis , Aminooxy group , Trifluoromethanesulfonamide , Trifluoromethanesulfonamidoxy , G-protein coupled receptor
Journal title
Tetrahedron Letters
Serial Year
2006
Journal title
Tetrahedron Letters
Record number
1852900
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