Stereoselective synthesis of functionalized 1,3 diols through the tandem isomerization–aldolization reaction mediated by nickel catalysts

A new approach to functionalized 1,3 diols, such as 15, is described using as the key step the tandem isomerization–aldolization reaction of allylic alcohols 1. The chiral imidazolidine group is shown to play a key role for the stereocontrol during aldolization and reduction steps.