Author/Authors :
Zheng، نويسنده , , Jifu and Li، نويسنده , , Yao-Xian and Zhang، نويسنده , , Suo-Qin and Yang، نويسنده , , Song-Tao and Wang، نويسنده , , Xiao-Ming and Wang، نويسنده , , Yong-Zhi and Bai، نويسنده , , Jie and Liu، نويسنده , , Fu-An، نويسنده ,
Abstract :
A series of new N-terminal prolyl-dipeptide derivatives have been synthesized and evaluated as organocatalysts for the direct asymmetric aldol reaction of acetone with electron-deficient aromatic aldehydes. At room temperature, the presence of 10 mol % of catalysts 2 and 5 efficiently catalyzes the direct asymmetric aldol reaction to give the aldol adducts with modest to excellent enantiomeric excesses (ee) values, which are up to 96%.
Keywords :
organocatalyst , N-terminal prolyl-dipeptide derivatives , direct aldol reaction , Asymmetric catalysis
