Title of article :
The ring opening of 3,4-dichloro-1,2,5-thiadiazole with metal amides. A new synthesis of 3,4-disubstituted-1,2,5-thiadiazoles
Author/Authors :
Merschaert، نويسنده , , Alain and Boquel، نويسنده , , Pascal and Gorissen، نويسنده , , Hugo and Hoeck، نويسنده , , Jean-Pierre Van and Borghese، نويسنده , , Alfio and Antoine، نويسنده , , Luc and Mancuso، نويسنده , , Vincent and Mockel، نويسنده , , Anne and Vanmarsenille، نويسنده , , Michel، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
We have developed a new synthesis of 3,4-disubstituted-1,2,5-thiadiazoles. The methodology is based on the ring opening of readily available 3,4-dichloro-1,2,5-thiadiazole with metal amides to afford a stable synthon, which is then transformed into the 3,4-disubstituted-1,2,5-thiadiazole derivatives via two consecutive reactions with O-, S-, N- or C-nucleophiles.
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
