Author/Authors :
Matsumoto، نويسنده , , Kazuya and Mitsuda، نويسنده , , Masaru and Ushijima، نويسنده , , Nobuto and Demizu، نويسنده , , Yosuke and Onomura، نويسنده , , Osamu and Matsumura، نويسنده , , Yoshihiro، نويسنده ,
Abstract :
Asymmetric desymmetrization of meso-vic-diols was achieved by carbamoylation in the presence of copper triflate and (S,S)-Ph-BOX as a catalyst without any use of bases. The method was successfully applied to asymmetric desymmetrization of five- to eight-membered cyclic meso-vic-diols in high enantioselectivity with up to 93% ee.
Keywords :
asymmetric desymmetrization , meso-vic-Diol , Carbamoylation , Chiral copper complex
