Title of article :
1,1-Dihydroperoxycyclododecane as a new, crystalline non-hygroscopic oxidizer for the chemical synthesis of oligodeoxyribonucleotides
Author/Authors :
Saneyoshi، نويسنده , , Hisao and Miyata، نويسنده , , Kenichi and Seio، نويسنده , , Kohji and Sekine، نويسنده , , Mitsuo، نويسنده ,
Abstract :
A new oxidation method for DNA synthesis was developed by the use of 1,1-dihydroperoxycyclododecane in CH2Cl2–EtOAc under anhydrous conditions. This new oxidizer was successfully applied to the synthesis of oligodeoxyribonucleotides that involves an oxidation step for conversion of phosphite intermediates to phosphate derivatives.
