Author/Authors :
Comabella، نويسنده , , Manuel and Rيo، نويسنده , , Jordi and Espejo، نويسنده , , Carmen and Ruiz de Villa، نويسنده , , Mamen and Al-zayat، نويسنده , , Hammad and Nos، نويسنده , , Carlos and Deisenhammer، نويسنده , , Florian and Baranzini، نويسنده , , Sergio E. and Nonell، نويسنده , , Lara and Lَpez، نويسنده , , Cristina and Julià، نويسنده , , Eva and Oksenberg، نويسنده , , Jorge R. and Montalban، نويسنده ,
Abstract :
Matrix metalloproteinases (MMPs) and tissue inhibitors (TIMPs) play a key role in the pathogenesis of multiple sclerosis (MS) and have been proposed as biomarkers of response to therapy. We investigated serum levels of several MMPs and TIMPs in 43 relapsing–remitting MS (RRMS) patients undergoing interferon-beta (IFN-b) treatment and classified as responders and non-responders based on clinical criteria. Levels of MMP-2, MMP-7, MMP-9, TIMP-1 and TIMP-2 were determined by ELISA before treatment and after 3, 6, 12, and 24 months of therapy. Neutralizing antibodies were determined by the myxovirus A induction bioassay. Treatment with IFN-b induced changes in levels of MMP-9 and TIMP-1. In contrast to non-responders, IFN-b resulted in an early and sustained increase in TIMP-1 levels in MS patients who showed clinical response to IFN-b. The early and sustained increase in TIMP-1 levels could be a marker of the response to IFN-b during the first 2 years of treatment.
