Title of article :
New strategy for the synthesis of phosphatase inhibitors TMC-69-6H and analogs
Author/Authors :
Brondel، نويسنده , , Nicolas and Renoux، نويسنده , , Brigitte and Gesson، نويسنده , , Jean-Pierre، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
An efficient method for the synthesis of antitumor TMC-69-6H and related analogs which have been demonstrated to be phosphatase (PTP1B, VHR, and PP1) inhibitors, is reported. This strategy involves two key steps: a diastereoselective aldol reaction and a one-pot tandem ring-closing and cross metathesis for the construction of the pyran moiety.
Keywords :
Antitumor activity , PTP1B inhibitor , metathesis , Diastereoselective aldolization , TMC-69-6H
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
