Title of article :
Stereoselective syntheses of unnatural steroidal C(20R) aldehydes by ionic hydrogenation of C-20 tertiary alcohols
Author/Authors :
Bapurao B. Shingate، نويسنده , , Bapurao B. and Hazra، نويسنده , , Braja G. and Pore، نويسنده , , Vandana S. and Gonnade، نويسنده , , Rajesh G. and Bhadbhade، نويسنده , , Mohan M.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2006
Abstract :
Syntheses of three unnatural steroidal C(20R) aldehydes have been realised from 16-dehydropregnenolone acetate. The salient feature of the synthesis is the ionic hydrogenation of C-20 tertiary alcohols leading to the formation of the C(20R) unnatural isomer with complete stereoselectivity. Oxidative hydrolysis of the dithiane moiety furnished the C(20R) aldehydes.
Keywords :
Unnatural C-20 aldehydes , oxidative hydrolysis , stereoselective synthesis , Ionic hydrogenation , 1 , 3-Dithiane
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
