• Title of article

    Overcoming steric effects in the coupling reaction of alkyloxycarbonyloxymethyl (AOCOM) halides with phenols: an efficient synthesis of AOCOM phenolic prodrugs

  • Author/Authors

    Thomas، نويسنده , , Joshua D. and Sloan، نويسنده , , Kenneth B.، نويسنده ,

  • Issue Information
    هفته نامه با شماره پیاپی سال 2007
  • Pages
    4
  • From page
    109
  • To page
    112
  • Abstract
    Steric hindrance is a key factor in the coupling reaction of AOCOM halides with phenols. Sterically unhindered alkoxy groups favor the formation of acylated phenol. Under phase-transfer conditions, alkylated phenol is favored regardless of steric hindrance.
  • Keywords
    Steric hindrance , Alkyloxycarbonyloxymethyl halide , phenol , Prodrug
  • Journal title
    Tetrahedron Letters
  • Serial Year
    2007
  • Journal title
    Tetrahedron Letters
  • Record number

    1853850

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=1853850