Title of article
Stereoselective synthesis of novel five-membered homoazasugars. A convenient route to all-cis tetrasubstituted pyrrolidines
Author/Authors
Elena Moreno-Clavijo، نويسنده , , Elena and Carmona، نويسنده , , Ana T. and Moreno-Vargas، نويسنده , , Antonio J. and Robina، نويسنده , , Inmaculada، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
159
To page
162
Abstract
We present a highly stereoselective procedure for the preparation of (2S and 2R,3S,4R,5S)-5-methyl-3,4-dihydroxy-2- ethoxycarbonylmethylpyrrolidines based on conjugate addition of ammonia to unsaturated aldonic esters derived from d-ribose followed by tandem cyclization. Derivatisation of these compounds to 2-hydroxyethyl-, benzymidazolylmethyl-, biphenyl-1-aminoethyl and naphthalene-l-aminoethyl-pyrrolidines is also presented.
Keywords
Pyrrolidines , azasugars , Iminosugars , Imino-C-glycosides , Homoazasugars , Glycosidase inhibitors
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1853867
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