Title of article
Stereoselective formal synthesis of the potent proteasome inhibitor: salinosporamide A
Author/Authors
Virginie Caubert، نويسنده , , Virginie and Massé، نويسنده , , Julien and Retailleau، نويسنده , , Pascal and Langlois، نويسنده , , Nicole، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
381
To page
384
Abstract
(2R,3S)-α-Methylenelactam 3, the key intermediate in Corey’s syntheses of salinosporamide A, has been synthesized from (S)-methyl 2-hydroxymethylpyroglutamate through chemoselective O-protection, regio- and stereoselective N-methylnitrone cycloaddition and quaternarization–elimination reactions as the main steps.
Keywords
Proteasome inhibitor , Salinosporamide A , pyroglutamate , 1 , 3-dipolar cycloadditions , N-Methylnitrone , Selective O-benzylation
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1853940
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