Author/Authors :
Hirose، نويسنده , , Tomoyasu and Sunazuka، نويسنده , , Toshiaki and Yamamoto، نويسنده , , Daisuke and Mouri، نويسنده , , Mutsumi and Hagiwara، نويسنده , , Yoshiaki and Matsumaru، نويسنده , , Takanori and Kaji، نويسنده , , Eisuke and ?mura، نويسنده , , Satoshi، نويسنده ,
Abstract :
The basic structure of the C(15)–C(27) part of irumamycin (1) was synthesized. Stereoselective assembly of C16, 17, 22, and an extra C21 stereocenter was achieved by two-directional Brown’s asymmetric allyl boration. Group selective PMP acetal formation and oxidative cleavage of vinyl group facilitated the differentiation of the ends of a two-directionally synthesized chain.
