Author/Authors :
Pornpakakul، نويسنده , , Surachai and Roengsumran، نويسنده , , Sophon and Deechangvipart، نويسنده , , Suchon and Petsom، نويسنده , , Amorn and Muangsin، نويسنده , , Nongnuch and Ngamrojnavanich، نويسنده , , Nattaya and Sriubolmas، نويسنده , , Nongluksna and Chaichit، نويسنده , , Narongsak and Ohta، نويسنده , , Tomihisa، نويسنده ,
Abstract :
A novel CYP3A4 inhibitor, diaporthichalasin, together with pycnidione were isolated from an endophytic fungus, Diaporthe sp. Their structures were elucidated on the basis of spectral data and the structure of diaporthichalasin was confirmed by X-ray crystallographic analysis. Diaporthichalasin exhibited significantly potent inhibition of CYP3A4 with an IC50 value of 0.626 μM, while the IC50 value of pycnidione was 465 μM.
Keywords :
endophytic fungi , cytochalasin , Phomopsichalasin , Diaporthe , CYP3A4 inhibitor , Secondary Metabolite
