Title of article :
Synthesis and activity of two trifluorinated analogues of 1-deoxy-d-xylulose 5-phosphate
Author/Authors :
Meyer، نويسنده , , Odile and Grosdemange-Billiard، نويسنده , , Catherine and Tritsch، نويسنده , , Denis and Rohmer، نويسنده , , Michel، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2007
Abstract :
An improved synthesis of 1,1,1-trifluoro-1-deoxy-d-xylulose 5-phosphate and an access to the reduced diastereomer mixture analogues 1,1,1-trifluoro-1-deoxy-d-xylitol 5-phosphate and 1,1,1-trifluoro-1-deoxy-d-lyxitol 5-phosphate are described. Inhibitor activity of all compounds on the MEP pathway for isoprenoid biosynthesis was evaluated.
Keywords :
1-deoxy-d-xylulose 5-phosphate reductoisomerase , Isoprenoid biosynthesis: 1 , 1-trifluoro-1-deoxy-d-xylulose 5-phosphate , 1
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
