Title of article
Synthesis and activity of two trifluorinated analogues of 1-deoxy-d-xylulose 5-phosphate
Author/Authors
Meyer، نويسنده , , Odile and Grosdemange-Billiard، نويسنده , , Catherine and Tritsch، نويسنده , , Denis and Rohmer، نويسنده , , Michel، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
711
To page
714
Abstract
An improved synthesis of 1,1,1-trifluoro-1-deoxy-d-xylulose 5-phosphate and an access to the reduced diastereomer mixture analogues 1,1,1-trifluoro-1-deoxy-d-xylitol 5-phosphate and 1,1,1-trifluoro-1-deoxy-d-lyxitol 5-phosphate are described. Inhibitor activity of all compounds on the MEP pathway for isoprenoid biosynthesis was evaluated.
Keywords
1-deoxy-d-xylulose 5-phosphate reductoisomerase , Isoprenoid biosynthesis: 1 , 1-trifluoro-1-deoxy-d-xylulose 5-phosphate , 1
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854047
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