Title of article
Short synthesis of 4-aryl-3-pyrrolin-2-ones
Author/Authors
Yoon-Miller، نويسنده , , Sarah J.P. and Opalka، نويسنده , , Suzanne M. and Pelkey، نويسنده , , Erin T.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
4
From page
827
To page
830
Abstract
A three step, convergent synthesis of 4-aryl-3-pyrrolin-2-ones from a tetramic acid has been developed. The key transformation utilized a Suzuki–Miyaura cross-coupling reaction between a 4-tosyloxy-3-pyrrolin-2-one and an arylboronic acid. This work also provides access to 4-arylpyrrolidin-2-ones, cyclic analogs of γ-aminobutyric acid (GABA). Hydrogenation of 4-(4′-chlorophenyl)-3-pyrrolin-2-one proceeded smoothly to give baclofen lactam.
Keywords
Pyrrol-2(5H)-one , Pyrrolidin-2-one , Tetramic acid , Suzuki–Miyaura reaction , Tosylate , 3-Pyrrolin-2-one
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854084
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