Author/Authors :
Ueda، نويسنده , , Masafumi and Ono، نويسنده , , Ayako and Nakao، نويسنده , , Dai and Miyata، نويسنده , , Okiko and Naito، نويسنده , , Takeaki، نويسنده ,
Abstract :
The total synthesis of penmacric acid and its stereoisomer, epipenmacric acid, is reported for the first time starting from trans-4-hydroxy-l-proline. Et3B-induced diastereoselective radical addition reaction was used to control stereoselectivity at the C3 stereogenic center as a key step.
