Title of article
Enantioselective vinylogous aldol reaction of Chan’s diene catalyzed by hydrogen-bonding
Author/Authors
Villano، نويسنده , , Rosaria and Acocella، نويسنده , , Maria Rosaria and Massa، نويسنده , , Antonio and Palombi، نويسنده , , Laura and Scettri، نويسنده , , Arrigo، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2007
Pages
5
From page
891
To page
895
Abstract
Hydrogen-bonding activation of aromatic aldehydes by a TADDOL-derivative promotes the vinylogous aldol reaction of Chan’s diene in moderate efficiency and enantioselectivity. Electron-poor aromatic aldehydes show an enhanced reactivity and a competing asymmetric hetero-Diels–Alder reaction takes place in comparable (or higher) yields and enantiomeric excesses.
Keywords
asymmetric synthesis , Vinylogous aldol reaction , hydrogen-bonding , Chan’s diene , organocatalysis
Journal title
Tetrahedron Letters
Serial Year
2007
Journal title
Tetrahedron Letters
Record number
1854105
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