Title of article :
Frequency of gC1qR+CD4+ T cells increases during acute hepatitis C virus infection and remains elevated in patients with chronic infection
Author/Authors :
Cummings، نويسنده , , Kara L. and Rosen، نويسنده , , Hugo R. and Hahn، نويسنده , , Young S.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
11
From page :
401
To page :
411
Abstract :
CD4+ T cell responses are impaired in chronic HCV infection. To determine factor(s) involved in CD4+ T cell dysregulation, we examined the effect of extracellular core on the alteration of CD4+ T cell responses and the cell surface level of core-binding protein, gC1qR on CD4+ T cells from acute HCV patients with resolved and chronic infection. During the acute phase of infection, the frequency of gC1qR+CD4+ T cells increased in both resolved and chronic HCV infection compared to healthy controls. Notably, 6 months later, the frequency of gC1qR+CD4+ T cells maintained elevated in chronic patients compared to that in resolved patients. In addition, TCR stimulation increased the frequency of gC1qR+CD4+ T cells, resulting in core-induced inhibition of T cell responses in both resolved and chronic patients. These results suggest that HCV infection expands gC1qR+CD4+ T cells, which increase the susceptibility to core-mediated immune dysregulation and facilitate the establishment of HCV persistency.
Keywords :
HCV , Extracellular core , CD4 T cells
Journal title :
Clinical Immunology
Serial Year :
2009
Journal title :
Clinical Immunology
Record number :
1854171
Link To Document :
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