Author/Authors :
Brunet، نويسنده , , Ernesto and Muٌoz، نويسنده , , Dulce Marيa and Parra، نويسنده , , Francisco and Mantecَn، نويسنده , , Susana and Juanes، نويسنده , , Olga and Rodrيguez-Ubis، نويسنده , , Juan Carlos and Carmen Cruzado، نويسنده , , Ma and Asensio، نويسنده , , Ramَn، نويسنده ,
Abstract :
A new method for the preparation of clarithromycin is described through the highly regioselective O-methylation at C(6)–OH of the novel derivative 9-pyrimidyloxime erythromycin A. The facile synthesis of 6,11-O-dimethyl- and 6,11,12-O-trimethyl erythromycin A is also reported. These compounds are useful as standards to assess clarithromycin purity in quality control processes.
